PTRF Antibody

CAT: 0223-7267-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7267-01Size:0.02 mg
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Background
PTRF Antibody: The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
NCBI Gene ID
284119
Swiss Prot
Q6NZI2
Accession Number
NP_036364
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
PTRF Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (95%), Mouse: (95%)
Buffer
PTRF Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PTRF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
43 kDa
Fragment
IgG
Specificity
At least three isoforms of PTRF are known to exist; this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.
Symbol
PTRF
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Polymerase I and transcript release factor
NCBI Organism
Homo sapiens
Background Reference 01
Jansa P, Mason SW, Hoffmann-Rohrer U, et al. Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 1998; 17:2855-64.
Background Reference 02
Vinten J, Johnsen AH, Roepstorff P, et al. Identification of a major protein on the cytosolic face of caveolae. Biochim. Biophys. Acta 2005; 1717:34-40.
Background Reference 03
Aboulaich N, Ortegren U, Vener AV, et al. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. Biochem. Biophys. Res. Commun. 2006; 350:657-61.
Background Reference 04
Aboulaich N, Chui PC, Asara JM, et al. Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes 2011; 60:757-65.
Other Product Names
PTRF Antibody: CGL4, CAVIN, CAVIN1, FKSG13, cavin-1, Polymerase I and transcript release factor, Cavin-1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
42734430
Physical Properties
Liquid

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