PTRF 1 Antibody

• Background:

  Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.

• NCBI Gene ID:

  284119

• Swiss Prot:

  Q6NZI2

• Accession Number:

  BAG60757

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide corresponding to the C terminal region.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Dry Ice

• Fragment:

  IgG

• Applications Notes:

  ELISA, Western (immuno) blotting, Immunostaining (in testing)

• Symbol:

  PTRF

• NCBI Official Name:

  Polymerase I and transcript release factor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function., Cell. 2008 Jan 11;132 (1) :23-4

• Other Product Names:

  2310075E07Rik, AW546441, Cavin, MGC118550, Cavin 1, CAVIN1, CGL4, FKSG13, FLJ90031, OTTMUSP00000002049, polymerase I and transcript release factor, RNA polymerase I and transcript release factor, RP23-279L23.6, TTF I interacting 12, CAVIN, cavin-1

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  56749614

• Physical Properties:

  Liquid