PTRF 1 Antibody

• Background :

  Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.

• NCBI Gene ID :

  284119

• Swiss Prot :

  Q6NZI2

• Accession Number :

  BAG60757

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide corresponding to the C terminal region.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Homeostasis

• Purification :

  Affinity Purified

• Concentration :

  Batch dependent

• Modification :

  None

• Shipping Conditions :

  Dry Ice

• Fragment :

  IgG

• Applications Notes :

  ELISA, Western (immuno) blotting, Immunostaining (in testing)

• Symbol :

  PTRF

• NCBI Official Name :

  Polymerase I and transcript release factor

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function., Cell. 2008 Jan 11;132 (1) :23-4

• Other Product Names :

  2310075E07Rik, AW546441, Cavin, MGC118550, Cavin 1, CAVIN1, CGL4, FKSG13, FLJ90031, OTTMUSP00000002049, polymerase I and transcript release factor, RNA polymerase I and transcript release factor, RP23-279L23.6, TTF I interacting 12, CAVIN, cavin-1

• Tested Applications :

  ELISA, WB, IHC

• Protein ID :

  56749614

• Physical Properties :

  Liquid