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SDPR Antibody

CAT: 0223-7265-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7265-01Size:0.02 mg
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Background
SDPR Antibody: The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.
NCBI Gene ID
8436
Swiss Prot
O95810
Accession Number
NP_004648
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
SDPR Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
SDPR Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SDPR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
It is predicted to not cross-react with other members of the cavin family.
Symbol
SDPR
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Serum deprivation response
NCBI Organism
Homo sapiens
Background Reference 01
Gustincich S, Vatta P, Goruppi S, et al. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics 1999; 57:120-9.
Background Reference 02
Hansen CG, Bright NA, Howard G, et al. SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 2009; 11:807-14.
Background Reference 03
Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.
Other Product Names
SDPR Antibody: SDR, CAVIN2, PS-p68, cavin-2, Serum deprivation-response protein, Cavin-2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4759082
Physical Properties
Liquid

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