SDPR Antibody

• Background:

  SDPR Antibody: The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

• NCBI Gene ID:

  8436

• Swiss Prot:

  O95810

• Accession Number:

  NP_004648

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  SDPR Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  SDPR Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SDPR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  It is predicted to not cross-react with other members of the cavin family.

• Symbol:

  SDPR

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Serum deprivation response

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gustincich S, Vatta P, Goruppi S, et al. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics 1999; 57:120-9.

• Background Reference 02:

  Hansen CG, Bright NA, Howard G, et al. SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 2009; 11:807-14.

• Background Reference 03:

  Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.

• Other Product Names:

  SDPR Antibody: SDR, CAVIN2, PS-p68, cavin-2, Serum deprivation-response protein, Cavin-2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  4759082

• Physical Properties:

  Liquid