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Anti-SDPR CAVIN2 Antibody

CAT: 0519-A31733Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A31733Size:0.1 mg
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Background
The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.
Description
Boster Bio Anti-SDPR CAVIN2 Antibody (Catalog # A31733) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Synonyms
SDR, CAVIN2, PS-p68, cavin-2, Serum deprivation-response protein, Cavin-2
Gene Name
SDPR
UniProt
O95810
Host
Rabbit
Reactivity
Human
Cross Reactivity
It is predicted to not cross-react with other members of the cavin family.
Immunogen
Rabbit polyclonal SDPR antibody was raised against an 18 amino acid peptide near the amino terminus of human SDPR. The immunogen is located within the first 50 amino acids of SDPR.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Cancer, Cell Cycle
Purification
SDPR Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939) . Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity) .
Molecular Weight
47173 MW
Shipping Conditions
Available
Storage Conditions
SDPR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Serum deprivation response
Subcellular Location
Cytoplasm, cytosol
Protein Name
Serum deprivation response

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