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TNFSF4 Antibody

CAT: 0223-7243-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7243-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ . TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
NCBI Gene ID
7292
Swiss Prot
P23510
Accession Number
NP_003317
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
TNFSF4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1466 - Rat Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (91%)
Buffer
TNFSF4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TNFSF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
20 kDa
Fragment
IgG
Specificity
At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms.
Symbol
TNFSF4
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 4
NCBI Organism
Homo sapiens
Background Reference 01
Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF) -nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.
Background Reference 02
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98
Other Product Names
TNFSF4 Antibody: GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40L
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4507603
Physical Properties
Liquid

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