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TYK2 Antibody

CAT: 0223-7177-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7177-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
NCBI Gene ID
7297
Swiss Prot
P29597
Accession Number
NP_003322
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
TYK2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Concentration
1 mg/mL
Buffer
TYK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TYK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 131 kDa
Fragment
IgG
Specificity
At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.
Symbol
TYK2
NCBI Official Name
Tyrosine kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Strobl B, Stoiber D, Sexl V, et al. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front. Biosci. 2011; 17:3214-32.
Other Product Names
TYK2 Antibody: JTK1, Non-receptor tyrosine-protein kinase TYK2
Tested Applications
ELISA, WB, IF
Protein ID
187608615
Physical Properties
Liquid

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