LMX1A Antibody

• Background:

  LMX1A Antibody: The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.

• NCBI Gene ID:

  4009

• Swiss Prot:

  Q8TE12

• Accession Number:

  NP_796372

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  LMX1A Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken: (92%)

• Buffer:

  LMX1A Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  LMX1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least two isoforms are known to exist. This antibody is predicted to not cross-react with LMX1B.

• Isoform:

  Human LMX1A has two isoforms, including isoform 1 (382aa, 42.7kD) and isoform 2 (133aa, 14.6kD) . Mouse LMX1A one isoform (382aa, 42.9kD), and ratt LMX1A has one isoform (382aa, 42.8kD) . 7087 can detect human, mouse and rat.

• Symbol:

  LMX1A

• Positive Control 2:

  Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

• Positive Control 3:

  Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate

• NCBI Official Name:

  LIM homeobox transcription factor 1, alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Failli et al. Mech. Dev. 2002; 118:225-8.

• Background Reference 02:

  Nakatani et al. Biol. 2010; 339:101-13.

• Background Reference 03:

  Chizhikov and Millen. Development 2004; 131:2693-705.

• Background Reference 04:

  Lin et al. Am. J. Clin. Pathol. 2012; 137:971-7.

• Other Product Names:

  LMX1A Antibody: LMX1, LMX1.1, LIM homeobox transcription factor 1-alpha

• Tested Applications:

  ELISA, ICC/IF, IHC-P, WB

• Protein ID:

  28893581

• Physical Properties:

  Liquid