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LMX1A Antibody

CAT: 0223-7087-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7087-01Size:0.02 mg
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Background
LMX1A Antibody: The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.
NCBI Gene ID
4009
Swiss Prot
Q8TE12
Accession Number
NP_796372
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
LMX1A Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (92%)
Buffer
LMX1A Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LMX1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms are known to exist. This antibody is predicted to not cross-react with LMX1B.
Isoform
Human LMX1A has two isoforms, including isoform 1 (382aa, 42.7kD) and isoform 2 (133aa, 14.6kD) . Mouse LMX1A one isoform (382aa, 42.9kD), and ratt LMX1A has one isoform (382aa, 42.8kD) . 7087 can detect human, mouse and rat.
Symbol
LMX1A
Positive Control 2
Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate
Positive Control 3
Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate
NCBI Official Name
LIM homeobox transcription factor 1, alpha
NCBI Organism
Homo sapiens
Background Reference 01
Failli et al. Mech. Dev. 2002; 118:225-8.
Background Reference 02
Nakatani et al. Biol. 2010; 339:101-13.
Background Reference 03
Chizhikov and Millen. Development 2004; 131:2693-705.
Background Reference 04
Lin et al. Am. J. Clin. Pathol. 2012; 137:971-7.
Other Product Names
LMX1A Antibody: LMX1, LMX1.1, LIM homeobox transcription factor 1-alpha
Tested Applications
ELISA, ICC/IF, IHC-P, WB
Protein ID
28893581
Physical Properties
Liquid

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