BATF Antibody

CAT: 0223-7069-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7069-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BATF Antibody: BATF is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events and blocks cellular transformation by Ras and Fos. BATF also is required for the differentiation of IL-17-producing T helper (TH17) cells, a CD4+ subset of T cells that coordinates the inflammatory response in host defense. In both T cells and B cells, BATF is required for the appropriate regulation of the class-switch recombination.
NCBI Gene ID
10538
Swiss Prot
Q16520
Accession Number
NP_006390
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
BATF Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1466 - Rat Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
BATF Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BATF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
14 kDa
Fragment
IgG
Specificity
Multiple isoforms of BATF are known to exist. Despite its predicted molecular weight, BATF often migrates at a higher than expected molecular weight.
Symbol
BATF
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Basic leucine zipper transcription factor, ATF-like
NCBI Organism
Homo sapiens
Background Reference 01
Dorsey MJ, Tae HJ, Sollenberger KG, et al. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene 1995; 11:2255-65.
Background Reference 02
Echlin DR, Tae HJ, Mitin N, et al. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. Oncogene 2000; 19:1752-63.
Background Reference 03
Schraml BU, Hildner K, Ise W, et al. The AP-1 transcription factor Batf controls TH17 differentiation. Nature 2009; 460:405-9.
Background Reference 04
Ise W, Kohyama M, Schraml BU, et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 2011; 12:536-43.
Other Product Names
BATF Antibody: SFA2, B-ATF, BATF1, SFA-2, Basic leucine zipper transcriptional factor ATF-like, B-cell-activating transcription factor
Tested Applications
ELISA, WB, IF
Protein ID
5453563
Physical Properties
Liquid

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