BATF3 Antibody

• Background:

  BATF3, also known as SNFT, belongs to the basic leucine zipper transcriptional family and functions as a transcriptional repressor when heterodimerizing with Jun (1) and can repress the transcription of IL-2 and MMP-1 (1,2) . BATF3 is required for the development of CD8alpha+ classical dendritic cells (DCs) and the related CD103+ DCs that cross-present antigens to CD8 T cells (3,4) .

• NCBI Gene ID:

  55509

• Swiss Prot:

  Q9NR55

• Accession Number:

  NP_061134

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Stem Cell

• Purification:

  BATF3 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  BATF3 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BATF3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  BATF3 antibody is human, mouse and rat reactive. BATF3 antibody is predicted to have no cross-reactivity to other BATF family members.

• Symbol:

  BATF3

• NCBI Official Name:

  Basic leucine zipper transcription factor, ATF-like 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Iacobelli M, Wachsman W, and McGuire KL. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J. Immunol. 2000; 154:860-8.

• Background Reference 02:

  Bower KE, Fritz JM, and McGuire KL. Transcriptional repression of MMP-1 by p21SNFT and reduced invasiveness of hepatocarcinoma cells. Oncogene 2004; 23:8805-14.

• Background Reference 03:

  Hildner K, Edelson BT, Purtha WE, et al. BATF3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008; 322:1097-1100.

• Background Reference 04:

  Edelson BT, Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J. Exp. Med. 2010; 207:823-36.

• Other Product Names:

  Basic leucine zipper transcriptional factor ATF-like 3, SNFT, JDP1, JUNDM1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  8924246

• Physical Properties:

  Liquid