BATF3 Antibody

CAT: 0223-7939-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7939-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BATF3, also known as SNFT, belongs to the basic leucine zipper transcriptional family and functions as a transcriptional repressor when heterodimerizing with Jun (1) and can repress the transcription of IL-2 and MMP-1 (1,2) . BATF3 is required for the development of CD8alpha+ classical dendritic cells (DCs) and the related CD103+ DCs that cross-present antigens to CD8 T cells (3,4) .
NCBI Gene ID
55509
Swiss Prot
Q9NR55
Accession Number
NP_061134
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Stem Cell
Purification
BATF3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
BATF3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BATF3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
BATF3 antibody is human, mouse and rat reactive. BATF3 antibody is predicted to have no cross-reactivity to other BATF family members.
Symbol
BATF3
NCBI Official Name
Basic leucine zipper transcription factor, ATF-like 3
NCBI Organism
Homo sapiens
Background Reference 01
Iacobelli M, Wachsman W, and McGuire KL. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J. Immunol. 2000; 154:860-8.
Background Reference 02
Bower KE, Fritz JM, and McGuire KL. Transcriptional repression of MMP-1 by p21SNFT and reduced invasiveness of hepatocarcinoma cells. Oncogene 2004; 23:8805-14.
Background Reference 03
Hildner K, Edelson BT, Purtha WE, et al. BATF3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008; 322:1097-1100.
Background Reference 04
Edelson BT, Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J. Exp. Med. 2010; 207:823-36.
Other Product Names
Basic leucine zipper transcriptional factor ATF-like 3, SNFT, JDP1, JUNDM1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
8924246
Physical Properties
Liquid

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