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VAMP7 Antibody

CAT: 0223-6929-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6929-01Size:0.02 mg
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Background
VAMP7 Antibody: VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
NCBI Gene ID
6845
Swiss Prot
P51809
Accession Number
NP_001172112
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
VAMP7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1402 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%), Bovine: (100%)
Buffer
VAMP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VAMP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of VAMP7 are known to exist; this antibody will detect the two longest isoforms. This antibody is predicted to not cross-react with other Ras-related proteins.
Symbol
VAMP7
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Vesicle-associated membrane protein 7
NCBI Organism
Homo sapiens
Background Reference 01
Galli T, Zahraoui A, Vaidyanathan VV, et al. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol. Biol. Cell 1998; 9:1437-48.
Background Reference 02
Wang Y and Tang BL. SNAREs in neurons - beyond synaptic vesicle exocytosis. Mol. Membr. Biol. 2006; 23:377-84.
Background Reference 03
Advani RJ, Yang B, Prekeris R, et al. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J. Cell Biol. 1999; 146:765-75.
Background Reference 04
Burgo A, Sotirakis E, Simmler MC, et al. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner in neurite growth. EMBO Rep. 2009; 10:1117-24.
Other Product Names
VAMP7 Antibody: SYBL1, TIVAMP, VAMP-7, TI-VAMP, SYBL1, Vesicle-associated membrane protein 7, Synaptobrevin-like protein 1
Tested Applications
ELISA, WB, IF
Protein ID
297747292
Physical Properties
Liquid

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