STOX1 Antibody

• Background:

  STOX1 Antibody: STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.

• NCBI Gene ID:

  219736

• Swiss Prot:

  Q6ZVD7

• Accession Number:

  NP_689922

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  STOX1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1304 - Human Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  STOX1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  STOX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  STOX1 antibody is human reactive. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. STOX1 antibody recognize the two longest isoforms.

• Symbol:

  STOX1

• NCBI Official Name:

  Storkhead box 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Van Dijk M, van Bezu J, Chim SS, et al. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat. Genet. 2005; 37:514-9.

• Background Reference 02:

  Kivinen K, Peterson H, Hiltunen L, et al. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur. J. Hum. Genet. 2007;15:494-7.

• Background Reference 03:

  Van Dijk M, van Bezu J, van Abel D, et al. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol. Genet. 2010; 19:2658-67.

• Background Reference 04:

  Van Abel D, Hölzel DR, Jain S, et al. SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. PLoS One 2011; 6 :e21994.

• Other Product Names:

  STOX1 Antibody: PEE4, C10orf24, Storkhead-box protein 1, Winged-helix domain-containing protein

• Tested Applications:

  ELISA, WB

• Protein ID:

  63025200

• Physical Properties:

  Liquid