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TTYH1 Antibody

CAT: 0223-6883-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6883-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TTYH1 Antibody: TTYH1 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH1 is a Ca2+-independent, volume-sensitive large conductance chloride (Cl-) channel. TTYH1 is primarily expressed in neural tissue and upregulated in astrocytoma, glioma, and several other cancers. Recent experiments have shown that TTYH1 is an integral endoplasmic reticulum (ER) membrane protein involved in cell proliferation and is thought to play an essential role in embryonic cell growth, possibly through the Ca2+ storage/release process in ER membranes during early development.
NCBI Gene ID
57348
Swiss Prot
Q9H313
Accession Number
NP_001005367
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
TTYH1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1207 - Raji Cell Lysate
Concentration
1 mg/mL
Buffer
TTYH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TTYH1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
TTYH1 antibody is human specific. Multiple isoforms of TTYH1 are known to exist.
Symbol
TTYH1
Positive Control 2
Cat. No. 17-007 - Raji Cell Slide
NCBI Official Name
Tweety homolog 1 (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Campbell HD, Kamei M, Caludianos C, et al. Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. Genomics 2000; 68:89-92.
Background Reference 02
Matthews CA, Shaw JE, Hooper JA, et al. Expression and evolution of the mammalian brain gene Ttyh1. J. Neurochem. 100:693-707
Background Reference 03
Kumada T, Yamanaka Y, Kitano A, et al. Ttyh1, a Ca2+-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev. Dyn. 2010; 239:2233-45.
Other Product Names
TTYH1 Antibody: Protein tweety homolog 1, hTTY1
Tested Applications
ELISA, WB, ICC
Protein ID
53831989
Physical Properties
Liquid

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