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PTPRD Antibody

CAT: 0223-6875-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6875-01Size:0.02 mg
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Background
PTPRD Antibody: PTPRD (Protein tyrosine phosphatase receptor type D) is a member of the protein tyrosine phosphatase (PTP) family that plays diverse roles during development including cell growth, differentiation, mitotic cycle and oncogenic transformation. PTPRD contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The extracellular region of PTPRD is composed of three Ig-like and eight fibronectin type III-like domains (1,3) . PTPRD interacts with PPFIA1-3 and is a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme (GBMs) and multiple human cancers.
NCBI Gene ID
5789
Swiss Prot
P23468
Accession Number
NP_569075
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
PTPRD Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Buffer
PTPRD Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PTPRD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
PTPRD antibody is human specific. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. PTPRD cleavage products are often observed in vivo
Symbol
PTPRD
NCBI Official Name
Protein tyrosine phosphatase, receptor type, D
NCBI Organism
Homo sapiens
Background Reference 01
Krueger NX, Streuli M, and Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990; 9:3241-52.
Background Reference 02
Fischer EH, Charbonneau H and Tonks NK. Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 1991; 253:401-6.
Background Reference 03
Pan MG, Rim C, Lu KP et al. Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene. J. Biol. Chem. 1993; 268:19284-91.
Background Reference 04
Veeriah S, Brennan C, Meng S, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc. Natl. Acad. Sci. USA 2009; 106: 9435-40.
Other Product Names
PTPRD Antibody: HPTP, PTPD, HPTPD, HPTPDELTA, RPTPDELTA, Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta
Tested Applications
ELISA, WB
Protein ID
289547551
Physical Properties
Liquid

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