TFEB Antibody

• Background:

  TFEB Antibody: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.

• NCBI Gene ID:

  7942

• Swiss Prot:

  P19484

• Accession Number:

  NP_009093

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy

• Purification:

  TFEB Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1203 - A549 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (100%)

• Buffer:

  TFEB Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TFEB antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TFEB

• Positive Control 2:

  Cat. No. 10-101 - Human Lung Tissue Slide

• NCBI Official Name:

  Transcription factor EB

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Carr CS and Sharp PA. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol. Cell Biol. 1990; 10:4384-8.

• Background Reference 02:

  Davis IJ, Hsi BL, Arroyo JD, et al. Cloning of an alpha-TFEB fusion in renal tumors harboring the t (6;11) (p21; q13) chromosome translocation. Proc. Natl. Acad. Sci. USA 2003; 100:6051-6.

• Background Reference 03:

  Sardiello M, Palmieri M, di Ronza A, et al. A gene network regulating lysosomal biogenesis and function. Science 2009; 325:473-7.

• Background Reference 04:

  Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, et al. Regulation of TFEB and V-ATPases my mTORC1. EMBO J. 2011; 30:3242-58

• Other Product Names:

  TFEB Antibody: TCFEB, BHLHE35, ALPHATFEB, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  24307933

• Physical Properties:

  Liquid