TFEC Antibody

• Background:

  Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) . Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity) . Collaborates with MITF in target gene activation (By similarity) . Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity) . Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity) . Binds DNA in a homo-or heterodimeric form.

• NCBI Gene ID:

  22797

• Swiss Prot:

  O14948

• Accession Number:

  O14948

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TFEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-205 amino acids from the Central region of human TFEC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TFEC

• NCBI Official Name:

  Transcription factor EC

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mansky, K.C., et al. J. Leukoc. Biol. 71 (2) :304-310 (2002)

• Background Reference 02:

  Chung, M.C., et al. Biochemistry 40 (30) :8887-8897 (2001)

• Background Reference 03:

  Steingrimsson, E., et al. Development 125 (23) :4607-4616 (1998)

• Background Reference 04:

  Yasumoto, K., et al. Biochim. Biophys. Acta 1353 (1) :23-31 (1997)

• Other Product Names:

  Transcription factor EC, TFE-C, Class E basic helix-loop-helix protein 34, bHLHe34, Transcription factor EC-like, hTFEC-L, TFEC, BHLHE34, TCFEC, TFECL

• Tested Applications:

  WB

• Physical Properties:

  Liquid