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TFEC Antibody

CAT: 0223-60-561Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-561Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) . Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity) . Collaborates with MITF in target gene activation (By similarity) . Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity) . Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity) . Binds DNA in a homo-or heterodimeric form.
NCBI Gene ID
22797
Swiss Prot
O14948
Accession Number
O14948
Host
Rabbit
Reactivity
Human
Immunogen
This TFEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-205 amino acids from the Central region of human TFEC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TFEC
NCBI Official Name
Transcription factor EC
NCBI Organism
Homo sapiens
Background Reference 01
Mansky, K.C., et al. J. Leukoc. Biol. 71 (2) :304-310 (2002)
Background Reference 02
Chung, M.C., et al. Biochemistry 40 (30) :8887-8897 (2001)
Background Reference 03
Steingrimsson, E., et al. Development 125 (23) :4607-4616 (1998)
Background Reference 04
Yasumoto, K., et al. Biochim. Biophys. Acta 1353 (1) :23-31 (1997)
Other Product Names
Transcription factor EC, TFE-C, Class E basic helix-loop-helix protein 34, bHLHe34, Transcription factor EC-like, hTFEC-L, TFEC, BHLHE34, TCFEC, TFECL
Tested Applications
WB
Physical Properties
Liquid

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