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TFE3 Antibody

CAT: 0223-59-796Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-796Size:400 µL
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Background
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1) ; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb) -TFE3 and ASPL-TFE3.
NCBI Gene ID
7030
Swiss Prot
P19532
Accession Number
P19532
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TFE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-516 amino acids from the C-terminal region of human TFE3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TFE3
NCBI Official Name
Transcription factor E3
NCBI Organism
Homo sapiens
Background Reference 01
Argani, P., et al. Am. J. Surg. Pathol. 34 (10) :1395-1406 (2010)
Background Reference 02
Haudebourg, J., et al. Cancer Genet. Cytogenet. 200 (2) :75-78 (2010)
Background Reference 03
Chang, I.W., et al. Am. J. Surg. Pathol. 33 (12) :1894-1901 (2009)
Background Reference 04
Yamaguchi, T., et al. Acta Cytol. 53 (6) :693-697 (2009)
Other Product Names
Transcription factor E3, Class E basic helix-loop-helix protein 33, bHLHe33, TFE3, BHLHE33
Tested Applications
WB
Protein ID
160113240
Physical Properties
Liquid

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