NCLN Antibody

• Background:

  NCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.

• NCBI Gene ID:

  56926

• Swiss Prot:

  Q969V3

• Accession Number:

  NP_064555

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  NCLN Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1401 - Mouse Heart Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  NCLN Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  NCLN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  NCLN

• Positive Control 2:

  Cat. No. 10-501 - Human Heart Tissue Slide

• NCBI Official Name:

  Nicalin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Haffner C, Frauli M, Topp S, et al. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. EMBO J. 2004; 23:3041-50.

• Background Reference 02:

  Dettmer U, Kuhn PH, Abou-Ajram C, et al. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J. Biol. Chem. 2010; 285:26174-81.

• Other Product Names:

  NCLN Antibody: NET59, Nicalin, Nicastrin-like protein

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  51873031

• Physical Properties:

  Liquid