Periphilin Antibody

• Background:

  Periphilin Antibody: Periphilin, known as PPHLN1 or gastric cancer antigen Ga50, plays a role in epithelial differentiation and contributes to epidermal integrity and barrier formation. It interacts with periplakin, a known precursor of the cornified cell envelope. Periphilin 1 is ubiquitously expressed and localizes to nucleus and cytoplasm. Existing as eight alternatively spliced isoforms, Periphilin is highly insoluble and contains a putative nuclear localization signal (NLS) within its N-terminal half, a prerequisite for the formation of insoluble complexes and a possible caspase recognition sequence and a potential nuclear export signal. Periphilin may play an important role in the nervous system.

• NCBI Gene ID:

  51535

• Swiss Prot:

  Q8NEY8

• Accession Number:

  NP_958848

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  Periphilin Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1411 - Mouse Colon Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  Periphilin Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Periphilin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PPHLN1

• NCBI Official Name:

  Periphilin 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kazerounian S and Aho S. Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. J. Biol. Chem. 2003; 278:36707-17.

• Background Reference 02:

  Kurita M, Suzuki H, Masai H, et al. Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Biochem. Biophys. Res. Commun. 2004; 324:554-61

• Background Reference 03:

  Soehn AS, Pham TT, Schaeferhoff K, et al. Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development. Genesis 2009; 47:697-707

• Background Reference 04:

  Soehn AS, Franck T, Biskup S, et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics 2010; 11:203-15

• Other Product Names:

  Periphilin Antibody: HSPC206, HSPC232, Periphilin-1, Gastric cancer antigen Ga50

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  48255929

• Physical Properties:

  Liquid