Peripherin Antibody [7C5]

CAT: 0223-50-258Size: 0.1 mLDry Ice: NoHazardous: No
CAT#:0223-50-258Size:0.1 mL
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Background
Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
NCBI Gene ID
24688
Swiss Prot
P21807
Accession Number
P21807
Host
Mouse
Reactivity
Mammal
Immunogen
Recombinant rat peripherin expressed in and purified from E. coli.
Clonality
Monoclonal
Clone
7C5
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Total IgG fraction
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Peripherin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
57
Fragment
IgG1
Specificity
Specific for the ~57kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.
Symbol
Prph
NCBI Official Name
Peripherin
NCBI Organism
Rattus norvegicus
Background Reference 01
Terao E, Janssens S, van den Bosch de Aquilar P, Portier M, Klosen P (2000) In vivo expression of the intermediate filament peripherin in rat motoneurons: modulation by inhibitory and stimulatory signals. Neuroscience 101 (3) :679-88.
Background Reference 02
Roberson J, Doroudchi MM, Nguyen MD, Durham, HD, Shaw G, Julien JP, Mushynski WE. (2003) A neurotoxic peripherin splice variant in a mouse model of ALS. J. Cell Biol. 160 (6) :939-49.
Background Reference 03
Boitard C, Villa MC, Becourt C, Gia HP, Huc C, Sempe P, Portier MM, Bach JF (1992) Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. Proc Natl Acad Sci USA 89 (1) :172-6.
Tested Applications
WB, IHC
Protein ID
129822
Physical Properties
Liquid

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