PRICKLE1 Antibody

CAT: 0223-6561-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6561-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2) . It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.
NCBI Gene ID
144165
Swiss Prot
Q96MT3
Accession Number
NP_694571
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
PRICKLE1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1310 - Human Bladder Tissue Lysate
Concentration
1 mg/mL
Buffer
PRICKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PRICKLE1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.
Symbol
PRICKLE1
NCBI Official Name
Prickle homolog 1
NCBI Organism
Homo sapiens
Background Reference 01
Katoh M and Katoh M. Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle. Int. J. Mol. Med. 2003; 11:249-56
Background Reference 02
Shimojo M and Hersh LB. REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. Mol. Cell. Biol. 2003; 23:9025-31
Background Reference 03
Chan DW, Chan CY, Yam JW, et al. Prickle1 negatively regulates Wnt/β -catenin pathway by promoting Disheveled ubiquitination/degradation in liver cancer. Gastroenterology 2006; 131:1218-27.
Background Reference 04
Tao H, Manak JR, Sowers L, et al. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am. J. Hum. Genet. 2011; 88:138-49.
Other Product Names
PRICKLE1 Antibody: RILP, EPM1B, RILP, Prickle-like protein 1
Tested Applications
ELISA, WB, IF
Protein ID
222136684
Physical Properties
Liquid

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