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ECRG1 Antibody

CAT: 0223-6521-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6521-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ECRG1 Antibody: Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.
NCBI Gene ID
339967
Swiss Prot
Q6ZMR5
Accession Number
Q6ZMR5
Host
Chicken
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ECRG1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1404 - Mouse Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
ECRG1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ECRG1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgY
Specificity
At least two isoforms of ECRG1 are known to exist; ECRG1 antibody is predicted to not cross-react with other ECRG family members.
Symbol
TMPRSS11A
NCBI Official Name
Transmembrane protease, serine 11A
NCBI Organism
Homo sapiens
Background Reference 01
Yueying W, Jianbo W, Hailin L, et al. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. Carcinogenesis 2008; 29:157-60.
Background Reference 02
Zhao N, Wang J, Cui Y, et al. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. J. Cell Biochem. 2004; 92:65-76
Background Reference 03
Zhao N, Huang G, Guo L, et al. ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. Exp. Biol. Med. 2006; 231:84-90.
Other Product Names
ECRG1 Antibody: ECRG1, ECRG1, HATL1, HESP, Transmembrane protease serine 11A, Airway trypsin-like protease 1
Tested Applications
ELISA, WB
Protein ID
167466250
Physical Properties
Liquid

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