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ECRG4 Antibody

CAT: 0223-6535-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6535-01Size:0.02 mg
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Background
ECRG4 Antibody: The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.
NCBI Gene ID
84417
Swiss Prot
Q9H1Z8
Accession Number
Q9H1Z8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ECRG4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (75%)
Buffer
ECRG4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ECRG4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
ECRG4 antibody is predicted to not cross-react with other ECRG family members.
Symbol
C2orf40
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Chromosome 2 open reading frame 40
NCBI Organism
Homo sapiens
Background Reference 01
Su T, Liu H, and Lu S. Cloning and identification of cDNA fragments related to human esophageal cancer. Zhonghua Zhong Liu Za Zhi 1998; 20:254-7.
Background Reference 02
Yue CM, Deng DJ, Bi MX, et al. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J. Gastroenterol. 2003; 9:1174-8.
Background Reference 03
Kujuro Y, Suzuki N, and Kondo T. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc. Natl. Acad. Sci. USA 2010; 107:8259-64.
Other Product Names
ECRG4 Antibody: ECRG4, ECRG4, UNQ761/PRO1508, Augurin, Esophageal cancer-related gene 4 protein
Tested Applications
ELISA, WB, ICC
Protein ID
14165276
Physical Properties
Liquid

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