SDHAF2 Antibody

• Background:

  SDHAF2 Antibody: SDHAF2 (Succinate dehydrogenase complex assembly factor 2) encodes a mitochondrial protein needed for FAD cofactor attach to the SDH enzyme which plays a critical role in mitochondria. SDHAF2 is a tumor suppressor, but recent evidence suggests that somatic mutations of the SDHAF2 are unlikely to contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.

• NCBI Gene ID:

  54949

• Swiss Prot:

  Q9NX18

• Accession Number:

  NP_060311

• Host:

  Chicken

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  SDHAF2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (93%)

• Buffer:

  SDHAF2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SDHAF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgY

• Specificity:

  SDHAF2 antibody is predicted to not cross-react with other SDHAF protein family members.

• Symbol:

  SDHAF2

• NCBI Official Name:

  Succinate dehydrogenase complex

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 2009; 325:1139-42.

• Background Reference 02:

  Burnichon N, Brière JJ, Libé R, et al. SDHA is a tumor suppressor gene causing paraganglioma. Hum. Mol. Genet. 2010; 19:3011-20.

• Background Reference 03:

  Kunst HP, Rutten MH, de Monnink JP, et al. SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma. Clin. Cancer Res. 2011; 17:247-54

• Background Reference 04:

  Starker LF, Delgado-Verdugo A, Udelsman R, et al. Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism. Endocrine 2010; 38:397-401.

• Other Product Names:

  SDHAF2 Antibody: PGL2, SDH5, C11orf79, PGL2, Succinate dehydrogenase assembly factor 2, mitochondrial, Succinate dehydrogenase subunit 5, SDH assembly factor 2

• Tested Applications:

  ELISA, WB

• Protein ID:

  8923450

• Physical Properties:

  Liquid