DBX1 Antibody

• Background:

  DBX1 Antibody: DBX1 is implicated in patterning the central nervous system during embryogenesis. DBX1 homeodomain transcription factor is expressed in progenitors which are critical in establishing cell fate allocation and cell diversity. DBX1 has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. DBX1-derived neurons are essential for the transgenic expression and generation of respiratory behavior both in vitro and in vivo.

• NCBI Gene ID:

  120237

• Swiss Prot:

  A6NMT0

• Accession Number:

  NP_001025036

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  DBX1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1405 - Mouse Kidney Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (87%)

• Buffer:

  DBX1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  DBX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  BX1 antibody is predicted to not cross-react with other DBX protein family members

• Symbol:

  DBX1

• Positive Control 2:

  Cat. No. 10-401 - Human Kidney Tissue Slide

• NCBI Official Name:

  Developing brain homeobox 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Griveau A, Borello U, Causeret F, et al. A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium. PLoS Biol. 2010; 8 (7) :e1000440

• Background Reference 02:

  Causeret F, Ensini M, Teissier A, et al. Dbx1-expressing cells are necessary for the survival of the Mammalian anterior neural and craniofacial structures. PLoS One 2011; 6:e19367.

• Background Reference 03:

  Pierani A, Moran-Rivard L, Sunshine MJ, et al. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron 2001; 29:367-84

• Background Reference 04:

  Gray PA, Hayes JA, Ling GY, et al. Developmental origin of preBotzinger complex respiratory neurons. J. Neurosci. 2010; 30:14883-95.

• Other Product Names:

  DBX1 Antibody: Homeobox protein DBX1, Developing brain homeobox protein 1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  304434796

• Physical Properties:

  Liquid