ORMDL1 Antibody

• Background:

  ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD) . Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.

• NCBI Gene ID:

  94101

• Swiss Prot:

  Q9P0S3

• Accession Number:

  NP_057551

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  ORMDL1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1220 - SK-N-SH Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (94%)

• Buffer:

  ORMDL1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ORMDL1 antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  ORMDL1 antibody may cross-react with other ORMDL protein family members.

• Symbol:

  ORMDL1

• NCBI Official Name:

  ORM1-like 1 (S. cerevisiae)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hjelmqvist L, Tuson M, Marfany G, et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002; 3 (6) : RESEARCH0027

• Background Reference 02:

  Araki W, Takahashi-Sasaki N, Chui DH, et al. A family of membrane proteins associated with Presenilin expression and α -secretase function. FASEB J. 2007; 22: 819-827

• Background Reference 03:

  Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473

• Background Reference 04:

  Breslow DK, Collins SR, Bodenmiller B, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010; 463 (7284) :1048-53

• Other Product Names:

  ORMDL1 Antibody: ORM1-like protein 1, Adoplin-1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  189458852

• Physical Properties:

  Liquid