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SLAMF1 Antibody

CAT: 0223-6247-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6247-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP) .
NCBI Gene ID
6504
Swiss Prot
Q13291
Accession Number
NP_003028
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
SLAMF1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1472 - Rat Colon Tissue Lysate
Concentration
1 mg/mL
Buffer
SLAMF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLAMF1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
4 isoforms of SLAMF1 are known to exist; this antibody will is predicted to recognize all 4 isoforms. SLAMF1 antibody is predicted to not cross-react with other SLAM protein family members.
Symbol
SLAMF1
NCBI Official Name
Signaling lymphocytic activation molecule family member 1
NCBI Organism
Homo sapiens
Background Reference 01
Cocks BG, Chang CC, Carballido JM, et al. 1995. A novel receptor involved in T cell activation. Nature 1995; 376:260-3.
Background Reference 02
Tatsuo H, Ono N, Tanaka K, et al. SLAM (CDw150) is a cellular receptor for measles virus. Nature 2000; 406:893-7.
Background Reference 03
Aversa G, Chang CC, Carballido JM, et al. Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, Cyclosporin A-sensitive T cell proliferation and IFN-α production. J. Immunol. 1997; 158:4036-44.
Other Product Names
SLAMF1 Antibody: SLAM, CD150, CDw150, SLAM, Signaling lymphocytic activation molecule
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4506969
Physical Properties
Liquid

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