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CXXC5 Antibody

CAT: 0223-6111-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6111-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CXXC5 Antibody: CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 (also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling pathway during development. CXXC5 is upregulated in neural stem cells upon BMP4 stimulation, leading to decreased levels of the Wnt-signaling target AXIN2 and facilitated the response of the stem cells to Wnt3a. Recent reports suggest CXXC5 transcription is activated by the Wilms tumor 1 (WT1) transcription factor, and together are involved in the WNT/beta-catenin pathway and play a role in embryonic kidney development.
NCBI Gene ID
51523
Swiss Prot
Q7LFL8
Accession Number
NP_057547
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
CXXC5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
CXXC5 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CXXC5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of CXXC5 are known to exist. CXXC5 antibody is predicted to not cross-react with other CXXC protein family members.
Symbol
CXXC5
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
CXXC finger protein 5
NCBI Organism
Homo sapiens
Background Reference 01
Andersson T, Sodersten E, Duckworth JK, et al. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. J. Biol. Chem.2009; 284:3672-81.
Background Reference 02
Kim MS, Yoon SK, Bollig F, et al. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. J. Biol. Chem. 2010; 285:14585-93.
Other Product Names
CXXC5 Antibody: CF5, WID, RINF, HSPC195, CXXC-type zinc finger protein 5, Putative MAPK-activating protein PM08, CF5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
158261990
Physical Properties
Liquid

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