Products for Research Use Only
RegisterLogin

CXXC4 Antibody

CAT: 0223-6041-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-6041-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
NCBI Gene ID
80319
Swiss Prot
Q9H2H0
Accession Number
NP_079488
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
CXXC4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
CXXC4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CXXC4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CXXC4
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
CXXC finger protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Hino S, Kishida S, Michuie T, et al. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell Biol.2001; 21:330-42.
Background Reference 02
Kojima T, Shimazui T, Hinotsu S, et al. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. Oncogene2009; 28:297-305.
Other Product Names
CXXC4 Antibody: IDAX, IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
13376816
Physical Properties
Liquid

Related Products

CatalogName
42-231PCXXC4 Peptide
6041PCXXC4 Peptide
29-009CXXC1 Antibody
25-079CXXC1 Antibody
14-981CXXC1 Antibody
6111-01CXXC5 Antibody
14-980CXXC1 Antibody
58-511CXXC1 Antibody
19-875CXXC1 Antibody
6111-01mgCXXC5 Antibody

Alternative Products

CatalogName
DF14211-01CXXC4 Antibody

Popular Products