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KLOTHO Antibody

CAT: 223-6107-01Size: 0.02 mgDry Ice: NoHazardous: No
0.02 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
NCBI Gene ID
9365
Swiss Prot
Q9UEF7
Accession Number
NP_004786
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
6107
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar KLOTHO expression profile in human and mouse cell lines detected by two independent anti-KLOTHO antibodies that recognize different epitopes, 6107 against central domain and competitor antibody against human recombinant protein. KLOTHO proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines6107 competitor antibody Recombinant Protein Test (Figure 2) : Anti-KLOTHO antibodies (6107) detected human KLOTHO recombinant protein at different concentrations. Recombinant Protein Test6107
Field of Research
Signal Transduction
Purification
KLOTHO Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Buffer
KLOTHO Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KLOTHO antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Three isoforms of KLOTHO are known to exist.
Isoform
Human KLOTHO has 2 isoforms, including isoform 1 (1012aa, 116kD) and isoform 2 (549aa, 62kD) . Mouse KLOTHO has 2 isoforms, including isoform 1 (1014aa, 116kD) and isoform 2 (550aa, 62kD) . Rat KLOTHO has one isoform (1014aa, 117kD) . 6107 can detect human, mouse and rat.
Symbol
KL
Positive Control 2
Cat. No. 1204 - K562 Cell Lysate
Positive Control 3
Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 4
Cat. No. 1282 - 3T3/NIH Cell Lysate
NCBI Official Name
Klotho
NCBI Organism
Homo sapiens
Background Reference 01
Kuro-o et al. Nature1997; 390:45-51.
Background Reference 02
Kurosu et al. Science2005; 309:1829-33.
Background Reference 03
Liu et al. Science 2007; 317:803-6.
Background Reference 04
Wolf et al. Oncogene2008; 27:7094-105.
Other Product Names
KLOTHO Antibody: Klotho
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
24497614
Physical Properties
Liquid

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