ZIP1 Antibody

CAT: 0223-6081-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6081-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
ZIP1 Antibody: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κ B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
NCBI Gene ID
27173
Swiss Prot
Q9NY26
Accession Number
NP_055252
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ZIP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (88%)
Buffer
ZIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of ZIP1 are known to exist; this antibody will detect both isoforms. ZIP1 antibody is predicted not to cross-react with other ZIP family proteins.
Symbol
SLC39A1
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Solute carrier family 39 (zinc transporter), member 1
NCBI Organism
Homo sapiens
Background Reference 01
Lioumi M, Ferguson CA, Sharpe PT, et al. Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics 1999; 62:272-80.
Background Reference 02
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch. 2004; 447:796-800.
Background Reference 03
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta. 2003; 1611:16-30.
Background Reference 04
Costello LC and Franklin RB. The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol. Cancer. 2006; 5:17.
Other Product Names
ZIP1 Antibody: ZIP1, ZIRTL, IRT1, ZIP1, CGI-08, CGI-71, Zinc transporter ZIP1, Solute carrier family 39 member 1, ZIP-1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
21361423
Physical Properties
Liquid

Related Products

CatalogName
6081PZIP1 Peptide
6083-01ZIP2 Antibody
6085-01ZIP3 Antibody
6093-01ZIP7 Antibody
6097-01ZIP9 Antibody
6099-01ZIP10 Antibody
6105-01ZIP14 Antibody
4991-01mgZIP10 Antibody
6093-002mgZIP7 Antibody
6095-002mgZIP8 Antibody

Alternative Products

CatalogName
MBS8583350-01ZIP1 Antibody
abx345562-01Synaptonemal complex protein ZIP1 (ZIP1) Antibody
abx345565-01Synaptonemal complex protein ZIP1 (ZIP1) Antibody (Biotin)
abx345564-01Synaptonemal complex protein ZIP1 (ZIP1) Antibody (FITC)
abx345563-01Synaptonemal complex protein ZIP1 (ZIP1) Antibody (HRP)
340112-01ZIP1

Popular Products