ZIP3 Antibody

• Background:

  ZIP3 Antibody: The zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.

• NCBI Gene ID:

  29985

• Swiss Prot:

  Q9BRY0

• Accession Number:

  NP_653165

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  ZIP3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat: (94%), Bovine: (88%)

• Buffer:

  ZIP3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZIP3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  SLC39A3

• NCBI Official Name:

  Solute carrier family 39 (zinc transporter), member 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.

• Background Reference 02:

  Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.

• Background Reference 03:

  Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.

• Background Reference 04:

  Kambe T, Geiser J, Lahner B, et al. Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am. J. Physiol. Regul. Integr. Comp. Physiol.2008; 294:R1474-81.

• Other Product Names:

  ZIP3 Antibody: ZIP3, ZIP-3, ZIP3, Zinc transporter ZIP3, Solute carrier family 39 member 3

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  32490561

• Physical Properties:

  Liquid