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ZIP2 Antibody

CAT: 0223-6083-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6083-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ZIP2 Antibody: The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
NCBI Gene ID
29986
Swiss Prot
Q9NP94
Accession Number
NP_055394
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ZIP2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
ZIP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZIP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SLC39A2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Solute carrier family 39 (zinc transporter), member 2
NCBI Organism
Homo sapiens
Background Reference 01
Gaither LA and Eide DJ. Functional expression of the human hZIP2 zinc transporter. J. Biol. Chem.2000; 275:5560-4.
Background Reference 02
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
Background Reference 03
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
Background Reference 04
Kambe T, Geiser J, Lahner B, et al. Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am. J. Physiol. Regul. Integr. Comp. Physiol.2008; 294:R1474-81.
Other Product Names
ZIP2 Antibody: 6A1, ZIP2, ETI-1, ZIP-2, Zinc transporter ZIP2, 6A1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
156415986
Physical Properties
Liquid

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