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ZIP14 Antibody

CAT: 0223-6105-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6105-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ZIP14 Antibody: The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA) . ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
NCBI Gene ID
23516
Swiss Prot
Q15043
Accession Number
NP_001128625
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
ZIP14 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Buffer
ZIP14 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZIP14 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of ZIP14 are known to exist; this antibody will detect both isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.
Symbol
Slc39a14
NCBI Official Name
Solute carrier family 39 (zinc transporter), member 14
NCBI Organism
Homo sapiens
Background Reference 01
Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem. 2003; 278:50142-50.
Background Reference 02
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch. 2004; 447:796-800.
Background Reference 03
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta. 2003; 1611:16-30.
Background Reference 04
Taylor KM, Morgan HE, Johnson A, et al. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. FEBS Lett. 2005; 579:427-32.
Other Product Names
ZIP14 Antibody: NET34, ZIP14, cig19, LZT-Hs4, KIAA0062, Zinc transporter ZIP14, LIV-1 subfamily of ZIP zinc transporter 4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
205830424
Physical Properties
Liquid

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