Products for Research Use Only
RegisterLogin

APC6 Antibody

CAT: 0223-5729-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5729-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
APC6 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.
NCBI Gene ID
8881
Swiss Prot
Q13042
Accession Number
NP_003894
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
APC6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
APC6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
APC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CDC16
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Cell division cycle 16 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
JM Peters. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol.2006; 7:644-56.
Background Reference 02
Jorgensen PM, Graslund S, Betz R, et al. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene2001; 262:51-9.
Background Reference 03
Wang J, Dye BT, Rajashankar KR, et al. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC structure. Nat. Struct. Mol. Biol.2009; 16:987-9.
Other Product Names
APC6 Antibody: APC6, CUT9, ANAPC6, Cell division cycle protein 16 homolog, Anaphase-promoting complex subunit 6, APC6
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
118402580
Physical Properties
Liquid

Related Products

CatalogName
5729PAPC6 Peptide
30-627APC2 Antibody
29-679APCS Antibody
42-913Apcs Antibody
18-435APCS Antibody
5725-002mgAPC4 Antibody
5727-01mgAPC5 Antibody
5717-01mgAPC1 Antibody
5717-01APC1 Antibody
5721-002mgAPC2 Antibody

Alternative Products

CatalogName
70R-32339APC6 antibody
RN-12053-01Recombinant APC6 Antibody
APR06623GPolyclonal APC6 Antibody
KB-28049-01APC6 Antibody (Biotin)
C49201APC6 Conjugated Antibody
GTR18612229Cdc16/APC6 Antibody
398107-01APC6
MBS152508-01APC6 Peptide

Popular Products