PPAPDC1B Antibody

• Background:

  PPAPDC1B Antibody: Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.

• NCBI Gene ID:

  84513

• Swiss Prot:

  Q8NEB5

• Accession Number:

  NP_001096029

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  PPAPDC1B Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PPAPDC1B Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PPAPDC1B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PPAPDC1B

• NCBI Official Name:

  Phosphatidic acid phosphatase type 2 domain containing 1B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Takeuchi M, Harigai M, Momohara S, et al. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. Gene2007; 399:174-80.

• Background Reference 02:

  Bernard-Pierrot I, Gruel N, Stransky N, et al. Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer. Cancer Res.2008; 68:7165-75.

• Other Product Names:

  PPAPDC1B Antibody: DPPL1, HTPAP, DPPL1, Phosphatidate phosphatase PPAPDC1B, Phosphatidic acid phosphatase type 2 domain-containing protein 1B

• Tested Applications:

  ELISA, WB

• Protein ID:

  156523237

• Physical Properties:

  Liquid