PPAPDC2 Antibody

• Background :

  PPAPDC2 Antibody: PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.

• NCBI Gene ID :

  403313

• Swiss Prot :

  Q8IY26

• Accession Number :

  NP_982278

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Innate Immunity

• Purification :

  PPAPDC2 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1207 - Raji Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine: (93%)

• Buffer :

  PPAPDC2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  PPAPDC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  PPAPDC2

• Positive Control 2 :

  Cat. No. 17-007 - Raji Cell Slide

• NCBI Official Name :

  Phosphatidic acid phosphatase type 2 domain containing 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Fukunaga K, Arita M, Takahashi M, et al. Identification and functional characterization of a presqualene diphosphate phosphatase. J. Biol. Chem.2006; 281:9490-7.

• Background Reference 02 :

  Miriyala S, Subramanian T, Panchatcharam M, et al. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. J. Biol. Chem.2010 (epub) .

• Other Product Names :

  PPAPDC2 Antibody: PDP1, PSDP, bA6J24.6, Presqualene diphosphate phosphatase, Phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAP2 domain-containing protein 2

• Tested Applications :

  ELISA, WB, IF

• Protein ID :

  66773040

• Physical Properties :

  Liquid