PPAPDC3 Antibody

• Background:

  PPAPDC3 Antibody: PPAPDC3, also known as nuclear envelope transmembrane protein 39 (NET39), was initially discovered in an in silico screen for secreted or membrane proteins. It is a member of the PAP2 superfamily of phosphatases and haloperoxidases. PPAPDC3 has recently been shown to act as a negative regulator of myoblast differentiation by diminishing the activity of the mammalian target of rapamycin TOR. PPAPDC3 is highly expressed in cardiac and skeletal muscle and becomes strongly upregulated during cultured myoblast differentiation tissues. Overexpression of PPAPDC3 in myoblasts repressed myogenesis while knockdown by RNA interference promoted differentiation indicating its part in the regulatory mechanism for myogenesis.

• NCBI Gene ID:

  84814

• Swiss Prot:

  Q8NBV4

• Accession Number:

  EAW87966

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  PPAPDC3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1401 - Mouse Heart Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PPAPDC3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PPAPDC3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PPAPDC3

• NCBI Official Name:

  Phosphatidic acid phosphatase type 2 domain containing 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Otsuki T, Ota T, Nishikawa T, et al. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res.2005; 12:117-26.

• Background Reference 02:

  Liu GH, Guan T, Datta K, et al. Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol. Cell Biol.2009; 29:5800-12.

• Other Product Names:

  PPAPDC3 Antibody: NET39, C9orf67, Probable lipid phosphate phosphatase PPAPDC3, Phosphatidic acid phosphatase type 2 domain-containing protein 3

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  119608372

• Physical Properties:

  Liquid