MARVELD1 Antibody

• Background:

  MARVELD1 Antibody: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.

• NCBI Gene ID:

  83742

• Swiss Prot:

  Q9BSK0

• Accession Number:

  EAW49903

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  MARVELD1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1401 - Mouse Heart Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  MARVELD1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  MARVELD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  MARVELD1

• NCBI Official Name:

  MARVEL domain containing 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wang S, Li Y, Han F, et al. On of MARVELD1, a novel nuclear protein that is down-regulated in multiple cancers and silenced by DNA methylation. Cancer Lett.2009; 282:77-86.

• Background Reference 02:

  Alves PM, Levy N, Stevenson BJ, et al. Identification of tumor-associated antigens by large scale analysis of genes expressed in human colorectal cancer. Cancer Immun.2008; 8:11.

• Background Reference 03:

  Hatada I, Fukasawa M, and Kimura M. Genome-wide profiling of promoter methylation in human. Oncogene2006; 25:3059-64.

• Other Product Names:

  MARVELD1 Antibody: MRVLDC1, MARVEL domain-containing protein 1

• Tested Applications:

  ELISA, WB

• Protein ID:

  119570288

• Physical Properties:

  Liquid