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AGTR1 Antibody

CAT: 0223-5391-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5391-01Size:0.02 mg
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Background
AGTR1 Antibody: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitors from hematopoietic stem cells, indicating the diversity of the roles of AGTR1.
NCBI Gene ID
185
Swiss Prot
P30556
Accession Number
EAW78909
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
AGTR1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Guinea pig: (100%), Rabbit: (100%), Sheep: (94%), Bovine: (94%), Chicken: (81%)
Buffer
AGTR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AGTR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
AGTR1
NCBI Official Name
Angiotensin II receptor, type 1
NCBI Organism
Homo sapiens
Background Reference 01
Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med.2008; 10:560-574.
Background Reference 02
Miyazaki Y and Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol.2001; 128:89-97.
Background Reference 03
Tsubakimoto Y, Yamada H, Yokoi H, et al. Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells. Arterioscler. Thromb. Vasc. Biol.2009; 29:1529-36.
Other Product Names
AGTR1 Antibody: AT1, AG2S, AT1B, AT1R, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1B, AGTR1A, AT2R1B, Type-1 angiotensin II receptor, AT1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
119599315
Physical Properties
Liquid

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