AGTR1 Antibody

• Background:

  AGTR1 Antibody: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitors from hematopoietic stem cells, indicating the diversity of the roles of AGTR1.

• NCBI Gene ID:

  185

• Swiss Prot:

  P30556

• Accession Number:

  EAW78909

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  AGTR1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1405 - Mouse Kidney Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (100%), Guinea pig: (100%), Rabbit: (100%), Sheep: (94%), Bovine: (94%), Chicken: (81%)

• Buffer:

  AGTR1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  AGTR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  AGTR1

• NCBI Official Name:

  Angiotensin II receptor, type 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med.2008; 10:560-574.

• Background Reference 02:

  Miyazaki Y and Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol.2001; 128:89-97.

• Background Reference 03:

  Tsubakimoto Y, Yamada H, Yokoi H, et al. Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells. Arterioscler. Thromb. Vasc. Biol.2009; 29:1529-36.

• Other Product Names:

  AGTR1 Antibody: AT1, AG2S, AT1B, AT1R, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1B, AGTR1A, AT2R1B, Type-1 angiotensin II receptor, AT1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  119599315

• Physical Properties:

  Liquid