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NOTUM Antibody

CAT: 0223-5291-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5291-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NOTUM Antibody: In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by beta-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
NCBI Gene ID
147111
Swiss Prot
Q6P988
Accession Number
NP_848588
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
NOTUM Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
NOTUM Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NOTUM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NOTUM
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Notum pectinacetylesterase homolog (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Giraldez AJ, Copley RR, and Cohen SM. HSPG modification by the secreted enzyme Notum shapes the wingless morphogen gradient. Dev. Cell2002; 667-76.
Background Reference 02
Traister A, Shi W, and Filmus J. Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface. Biochem. J.2008; 410:503-11.
Background Reference 03
Torisu Y, Watanabe A, Nonaka A, et al. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by b-catenin/TCF. Cancer Sci.2008; 6:1139-46.
Other Product Names
NOTUM Antibody: Protein notum homolog
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
194394139
Physical Properties
Liquid

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