Products for Research Use Only
RegisterLogin

AP2M1 Antibody

CAT: 0223-5161-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5161-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
AP2M1 Antibody: The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA) -4 protein. At least two isoforms of AP2M1 are known to exist.
NCBI Gene ID
1173
Swiss Prot
Q96CW1
Accession Number
NP_004059
Host
Chicken
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
AP2M1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)
Buffer
AP2M1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AP2M1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgY
Symbol
AP2M1
NCBI Official Name
Adaptor-related protein complex 2, mu 1 subunit
NCBI Organism
Homo sapiens
Background Reference 01
Robinson MS. Adaptable adaptors for coated vesicles. Trends Cell Biol.2004; 14:167-74.
Background Reference 02
Aguilar RC, Ohno H, Roche KW, et al. Functional domain mapping of the clathrin-associated adaptor medium chains mu1 and mu J. Biol. Chem.1997; 272:27160-6.
Background Reference 03
Liu Q, Feng Y, and Forgac M. Activity and in vitro reassembly of the coated vesicle (H+) -ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2. J. Biol. Chem.1994; 269:31592-7.
Background Reference 04
Craig HM, Reddy TR, Riggs NL, et al. Interactions of HIV-1 Nef with the m subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology271:9-17.
Other Product Names
AP2M1 Antibody: mu2, AP50, CLAPM1, KIAA0109, AP-2 complex subunit mu, AP-2 mu chain
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14917109
Physical Properties
Liquid

Related Products

CatalogName
5161PAP2M1 Peptide
30-885AP2B1 Antibody
59-195AP2S1 Antibody
57-344AP2A1 Antibody
30-886AP2B1 Antibody
43-204AP2A1 Antibody
14-343AP2S1 Antibody
22-512AP2A1 Antibody
18-434AP2B1 Antibody
58-131AP2B1 Antibody

Alternative Products

CatalogName
10R-3331AP2M1 antibody

Popular Products