AP2A1 Antibody

• Background:

  This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma) . The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.

• NCBI Gene ID:

  160

• Swiss Prot:

  O95782

• Accession Number:

  O95782

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AP2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 706-735 amino acids from the C-terminal region of human AP2A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  108 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  AP2A1

• NCBI Official Name:

  AP-2 complex subunit alpha-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mitchell, R.S., et al. J. Virol. 82 (16) :7758-7767 (2008)

• Background Reference 02:

  Kitagawa, Y., et al. Virology 373 (1) :171-180 (2008)

• Background Reference 03:

  Stove, V., et al. J. Virol. 79 (17) :11422-11433 (2005)

• Background Reference 04:

  Lu, W., et al. Neuron 47 (3) :407-421 (2005)

• Other Product Names:

  AP-2 complex subunit alpha-1, 100 kDa coated vesicle protein A, Adaptor protein complex AP-2 subunit alpha-1, Adaptor-related protein complex 2 subunit alpha-1, Alpha-adaptin A, Alpha1-adaptin, Clathrin assembly protein complex 2 alpha-A large chain, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit, AP2A1, ADTAA, CLAPA1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid