Products for Research Use Only
RegisterLogin

POFUT1 Antibody

CAT: 0223-4765-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-4765-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
POFUT1 Antibody: POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
NCBI Gene ID
23509
Swiss Prot
Q9H488
Accession Number
NP_056167
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
POFUT1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (94%)
Buffer
POFUT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
POFUT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of POFUT1 are known to exist. This antibody is predicted to not cross-react with POFUT2.
Symbol
POFUT1
Positive Control 2
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
Protein O-fucosyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Wang Y, Shao L, Shi S, et al. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J. Biol. Chem.2001; 276:40338-45.
Background Reference 02
Loriol C, Dupuy F, Rampal R, et al. Molecular evolution of protein O-fucosyltransferase genes and splice variants. Glycobiology2006; 16:736-47.
Background Reference 03
Stahl M, Uemura K, Ge C, et al. Roles of POFUT1 and O-fucose in mammalian Notch signaling. J. Biol. Chem.2008; 283:13638-51.
Other Product Names
POFUT1 Antibody: DDD2, FUT12, O-FUT, OFUCT1, O-Fuc-T, O-FucT-1, KIAA0180, GDP-fucose protein O-fucosyltransferase 1, Peptide-O-fucosyltransferase 1
Tested Applications
ELISA, WB, IHC-P
Protein ID
27436889
Physical Properties
Liquid

Related Products

CatalogName
4765PPOFUT1 Peptide
30-124POFUT2 Antibody
56-696POFUT2 Antibody
26-081POFUT2 Antibody
14-323POFUT2 Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody

Alternative Products

CatalogName
70R-9775POFUT1 antibody

Popular Products