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APH1 Antibody

CAT: 0223-4003-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4003-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.
NCBI Gene ID
51107
Swiss Prot
Q96BI3
Accession Number
AAH08732
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
APH1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1283 - RAW 264.7 Cell Lysate
Concentration
1 mg/mL
Buffer
APH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
APH1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
APH1A
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Anterior pharynx defective 1 homolog A (C. elegans)
NCBI Organism
Homo sapiens
Background Reference 01
Goutte C, Tsunozaki M, Hale VA, et al. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA2002; 99:775-9.
Background Reference 02
Periz G and Fortini ME. Functional reconstitution of γ secretase through coordinated expression of presenilin, nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22.
Background Reference 03
Selkoe DJ. The cell biology of β amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 1998; 8:447-53.
Background Reference 04
Ma G, Li T, Price DL, et al. APH-1a is the principal mammalian aph-1 isoform present in g-secretase complexes during embryonic development. Neuro. Dis. 2005; 25:192-8.
Other Product Names
APH1 Antibody: APH-1, APH-1A, CGI-78, 6530402N02Rik, PSF, UNQ579/PRO1141, Gamma-secretase subunit APH-1A, Aph-1alpha, APH-1a
Tested Applications
ELISA, WB, IHC-P
Protein ID
14250557
Physical Properties
Liquid

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