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TANK Antibody

CAT: 0223-3877-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3877-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TANK Antibody: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κ B. This activation of NF-κ B occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Iκ B complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κ B proteins. At least two isoforms of TANK are known to exist.
NCBI Gene ID
10010
Swiss Prot
Q92844
Accession Number
NP_004171
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Neuroscience
Purification
TANK Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
TANK Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TANK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TANK
Positive Control 2
Cat. No. 1466 - Rat Spleen Tissue Lysate
NCBI Official Name
TRAF family member-associated NFKB activator
NCBI Organism
Homo sapiens
Background Reference 01
Cheng G and Baltimore D. TANK, a co-inducer with TRAF2 of TNF- and CD40L-mediated NF-κ B activation. Genes Dev. 1996; 10:963-73.
Background Reference 02
Rothe M, Xiong J, Shu HB, et al. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Natl. Acad. Sci. USA 1996; 93:8241-6.
Background Reference 03
Pomerantz JL and Baltimore D. NF-κ B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 1999; 18:6694-704.
Background Reference 04
Chariot A, Leonardi A, Muller J, et al. Association of the adaptor TANK with the Iκ B kinase (IKK) regulator NEMO connects IKK complexes with the IKKε and TBK1 kinases. J. Biol. Chem.2002; 277:37029-36.
Other Product Names
TANK Antibody: ITRAF, TRAF2, I-TRAF, ITRAF, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
19743569
Physical Properties
Liquid

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