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Clusterin Antibody

CAT: 0223-3856-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3856-01Size:0.02 mg
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Background
Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.
NCBI Gene ID
1191
Swiss Prot
P10909
Accession Number
NP_001822
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Clusterin antibody was raised recombinant human Clusterin isoform 1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Clusterin Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
Clusterin Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Clusterin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CLU
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Clusterin
NCBI Organism
Homo sapiens
Background Reference 01
Calero M, Rostagno A, Frangione B, et al. Clusterin and Alzheimer's disease. Subcell. Biochem. 2005; 38:273-98.
Background Reference 02
Martin-Rehrmann MD, Hoe HS, Capuani EM, et al. Association of apolipoprotein J-positive β -amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Neurotox. Res. 2005; 7:231-42.
Background Reference 03
Trougakos IP and Gonos ES. Clusterin/Apolipoprotein J in human aging and cancer. Int. J. Biochem. Cell Biol. 2002; 34:1430-48.
Background Reference 04
Martinon F and Tschopp J. NLRs join TLRs as innate sensors of pathogens. TRENDS Imm. 2005; 26:447-54.
Other Product Names
Clusterin Antibody: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2, CLI, Clusterin, Aging-associated gene 4 protein, Apo-J
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
42716297
Physical Properties
Liquid

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