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TWEAK Antibody

CAT: 0223-3791-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3791-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
NCBI Gene ID
8742
Swiss Prot
O43508
Accession Number
NP_003800
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
3791
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 2) : Anti-TWEAK antibodies (3791) detected human TWEAK recombinant protein at different concentrations. Recombinant Protein Test3791
Field of Research
Apoptosis, Cancer
Purification
TWEAK Antibody is Protein A-purified.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
TWEAK Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TWEAK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human TWEAK has 2 isoforms, including isoform 1 (249aa, 27kD) and isoform 2 (330aa, 36kD) . Mouse TWEAK has one isoform (249aa, 27kD) and Rat TWEAK also has one isoform (249aa, 27kD) .
Symbol
TNFSF12
Positive Control 2
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 3
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 12
NCBI Organism
Homo sapiens
Background Reference 01
Wiley and Winkles. Cyto. And Growth Factor Rev. 2003; 14:241-9.
Background Reference 02
Chicheportiche et al. J. Biol. Chem. 1997; 272:32401-10.
Background Reference 03
Lynch et al. J. Biol. Chem. 1999; 274:8455-9.
Background Reference 04
Chicheportiche et al. Arthr. Res. 2002; 4:126-33. 5.
Other Product Names
TWEAK Antibody: APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4507597
Physical Properties
Liquid

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