TWEAK Antibody

• Background:

  TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

• NCBI Gene ID:

  8742

• Swiss Prot:

  O43508

• Accession Number:

  NP_003800

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  3791

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Recombinant Protein Test (Figure 2) : Anti-TWEAK antibodies (3791) detected human TWEAK recombinant protein at different concentrations. Recombinant Protein Test3791

• Field of Research:

  Apoptosis, Cancer

• Purification:

  TWEAK Antibody is Protein A-purified.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TWEAK Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TWEAK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Human TWEAK has 2 isoforms, including isoform 1 (249aa, 27kD) and isoform 2 (330aa, 36kD) . Mouse TWEAK has one isoform (249aa, 27kD) and Rat TWEAK also has one isoform (249aa, 27kD) .

• Symbol:

  TNFSF12

• Positive Control 2:

  Cat. No. 1201 - HeLa Cell Lysate

• Positive Control 3:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 12

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wiley and Winkles. Cyto. And Growth Factor Rev. 2003; 14:241-9.

• Background Reference 02:

  Chicheportiche et al. J. Biol. Chem. 1997; 272:32401-10.

• Background Reference 03:

  Lynch et al. J. Biol. Chem. 1999; 274:8455-9.

• Background Reference 04:

  Chicheportiche et al. Arthr. Res. 2002; 4:126-33. 5.

• Other Product Names:

  TWEAK Antibody: APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  4507597

• Physical Properties:

  Liquid