TWEAK Recombinant Protein

• Background:

  TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-g. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.

• NCBI Gene ID:

  8742

• Swiss Prot:

  O43508

• Accession Number:

  NP_003800.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Apoptosis, Cancer, Chemokines & Cytokines, Other

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized TWEAK recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TWEAK is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TWEAK recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 12

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand

• Species:

  Human

• Protein ID:

  4507597

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3