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LSD1 Antibody

CAT: 0223-3761-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3761-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LSD1 Antibody: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.
NCBI Gene ID
23028
Swiss Prot
O60341
Accession Number
NP_001009999
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3761
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar LSD1 expression profile in human and mouse cell lines detected by two independent anti-LSD1 antibodies that recognize different epitopes, 3761 against N-terminus domain and 14-050 against recombinant fusion protein. LSD1 proteins are detected in the most tested cell lines that include mouse (3T3/NIH) and rat cell lines (YB2/0) at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3761 14-050
Field of Research
Homeostasis
Purification
LSD1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1286 - P815 Cell Lysate
Concentration
1 mg/mL
Buffer
LSD1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LSD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human LSD1 has 2 isoforms, including isoform 1 (852aa, 93kD) and isoform 2 (876aa, 95kD) . Mouse LSD1 has one isoform (853aa, 93kD) and Rat LSD1 also has one isoform (872aa, 95kD) . 3761 can detect all isoforms of human, mouse and rat.
Symbol
KDM1
Positive Control 2
Cat. No. 1224 - Daudi Cell Lysate
Positive Control 3
Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 4
Cat. No. 1211 – HepG2 Cell Lysate
NCBI Official Name
Lysine (K) -specific demethylase 1
NCBI Organism
Homo sapiens
Background Reference 01
Shi et al. Cell 2004; 119:941-53.
Background Reference 02
Kouzarides et al. Curr. Opin. Genet. Dev. 2002; 12:198-209.
Background Reference 03
Shi et al. Mol. Cell 2005; 19:857-64.
Background Reference 04
Nakamura et al. Mol. Cell 2002; 10:1119-28.
Other Product Names
LSD1 Antibody: AOF2, KDM1, LSD1, BHC110, AOF2, KIAA0601, Lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
58761544
Physical Properties
Liquid

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