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TAB2 Antibody

CAT: 0223-3389-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3389-01Size:0.02 mg
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Background
TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
NCBI Gene ID
23118
Swiss Prot
Q9NYJ8
Accession Number
NP_055908
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
TAB2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 10-301 - Human Brain Tissue Slide
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (86%), Mouse: (79%)
Buffer
TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TAB2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
Symbol
TAB2
NCBI Official Name
TGF-beta activated kinase 1/MAP3K7 binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 2000; 5:649-58.
Background Reference 02
Maizukami J, Takaesu G, Akatsuka H, et al. Receptor activation of NF-kappaB lingand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 2002; 22:992-1000.
Background Reference 03
Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.
Other Product Names
TAB2 Antibody: CHTD2, MAP3K7IP2, KIAA0733, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2
Tested Applications
ELISA, IHC-P
Protein ID
14149669
Physical Properties
Liquid

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